2. Signaling Pathways
  3. Membrane Transporter/Ion Channel
    Neuronal Signaling
  4. Calcium Channel

Calcium Channel

Ca2+ channels; Ca channels

Calcium Channel

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Calcium channel is an ion channel which displays selective permeability to calcium ions. It is sometimes synonymous as voltage-dependent calcium channel, although there are also ligand-gated calcium channels. Voltage-gated calcium (CaV) channels catalyse rapid, highly selective influx of Ca2+ into cells despite a 70-fold higher extracellular concentration of Na+. Some calcium channel blockers have the added benefit of slowing your heart rate, which can further reduce blood pressure, relieve chest pain (angina) and control an irregular heartbeat.

Calcium Channel Isoform Specific Products:

Calcium Channel Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-164648
    Flosatidil
    		Antagonist
    Flosatidil (SL 85.1016) is an orally active Calcium Channel antagonist. Flosatidil has antianginal and antihypertensive properties.
    Flosatidil
  • HY-B0768
    Lomerizine
    		Antagonist
    Lomerizine is an antagonist of L- and T-type voltagegated calcium channels.
    Lomerizine
  • HY-14275S1
    Verapamil-d7
    		Antagonist
    Verapamil-d7 is the deuterium labeled Verapamil (HY-14275). Verapamil ((±)-Verapamil) is a calcium channel blocker and a potent and orally active first-generation P-glycoprotein (P-gp) inhibitor. Verapamil also inhibits CYP3A4. Verapamil has the potential for high blood pressure, heart arrhythmias and angina research.
    Verapamil-d<sub>7</sub>
  • HY-122331
    Norbormide
    		Antagonist 98.91%
    Norbormide, a rodenticide, is a calcium entry blocker with a selective vasoconstrictor activity. Norbormide shows species- and tissue-specific, endothelium independent, and is restricted to the peripheral arteries of rat.
    Norbormide
  • HY-120985
    Araguspongin B
    		Antagonist
    Xestospongins and araguspongins are marine natural products first isolated from Pacific basin sponges, and noted to have vasodilatory properties.1 Inositol phosphates (IP) are important signal transduction messengers acting via IP3 receptors to promote the mobilization of Ca2+ from intracellular stores.2 Araguspongin B antagonizes the calcium-releasing action of inositol 1,4,5-trisphosphate at the receptor level in cerebral microsomes, with an IC50 of 0.6 μM. It is nearly as potent as xestospongin C as an antagonist of the IP3 receptor.
    Araguspongin B
  • HY-B0317AR
    Amlodipine maleate (Standard)
    		Antagonist
    Amlodipine (maleate) (Standard) is the analytical standard of Amlodipine (maleate). This product is intended for research and analytical applications. Amlodipine maleate is a dihydropyridine calcium channel blocker, acts as an orally active antianginal agent. Amlodipine maleate blocks the voltage-dependent L-type calcium channels, thereby inhibiting the initial influx of calcium. Amlodipine maleate can be used for the research of high blood pressure and cancer.
    Amlodipine maleate (Standard)
  • HY-103313
    SR33805 oxalate
    		Antagonist
    SR33805 oxalate is a potent Ca2+ channel antagonist, with EC50s of 4.1 nM and 33 nM in depolarized and polarized conditions, respectively. SR33805 oxalate blocks L-type but not T-type Ca2+ channels. SR33805 oxalate can be used for the research of acute or chronic failing hearts.
    SR33805 oxalate
  • HY-111499
    Emopamil
    		Antagonist
    Emopamil is an inhibitor of calcium channel that can reduce ischemia-induced neuronal cell damage.
    Emopamil
  • HY-14656R
    Diltiazem hydrochloride (Standard)
    		Antagonist
    Diltiazem (hydrochloride) (Standard) is the analytical standard of Diltiazem (hydrochloride). This product is intended for research and analytical applications. Diltiazem hydrochloride is a Ca2+ influx inhibitor (slow channel blocker or calcium antagonist).
    Diltiazem hydrochloride (Standard)
  • HY-N0215S6
    DL-Phenylalanine-d5 hydrochloride
    		Antagonist
    DL-Phenylalanine-d5 (hydrochloride) is the deuterium labeled DL-Phenylalanine hydrochloride. L-Phenylalanine hydrochloride is an essential amino acid isolated from Escherichia coli. L-Phenylalanine hydrochloride is a α2δ subunit of voltage-dependent Ca+ channels antagonist with a Ki of 980 nM. L-phenylalanine hydrochloride is a competitive antagonist for the glycine- and glutamate-binding sites of N-methyl-D-aspartate receptors (NMDARs) (KB of 573 μM ) and non-NMDARs, respectively. L-Phenylalanine hydrochloride is widely used in the production of food flavors and pharmaceuticals.
    DL-Phenylalanine-d<sub>5</sub> hydrochloride
  • HY-U00049A
    Mioflazine (di(hydrochloride) hydrate)
    		Antagonist
    Mioflazine dihydrochloride hydrate is a nucleoside transport inhibitor with sleep-improving activity. Mioflazine dihydrochloride hydrate helps maintain the mechanical function of the left ventricle and significantly improves the heart's recovery ability after global ischemia at new temperatures. Mioflazine dihydrochloride hydrate reduces the mitochondrial calcium content in guinea-pig.
    Mioflazine (di(hydrochloride) hydrate)
  • HY-P1078A
    Huwentoxin XVI TFA
    		Antagonist
    Huwentoxin XVI TFA, an analgesic, is a highly reversible and selective mammalian N-type calcium channel (IC50 of ~60 nM) antagonist from Chinese tarantula Ornithoctonus huwena. Huwentoxin XVI TFA has no effect on voltagegated T-type calcium channels, potassium channels or sodium channels.
    Huwentoxin XVI TFA
  • HY-108997
    Palonidipine
    		Antagonist
    Palonidipine is a calcium antagonist which is potential for the therapy of angina-pectoris and hypertension.
    Palonidipine
  • HY-14656S1
    Diltiazem-(acetoxy-d3) hydrochloride
    		Antagonist
    Diltiazem-(acetoxy-d3) (hydrochloride) is the deuterium labeled Diltiazem hydrochloride. Diltiazem hydrochloride is a Ca2+ influx inhibitor (slow channel blocker or calcium antagonist)[1][2].
    Diltiazem-(acetoxy-d<sub>3</sub>) hydrochloride
  • HY-19409
    AJG049
    		Antagonist
    AJG049 is a novel antagonist of the Ca2+ channel with an IC50 value of 79 nM. AJG049 can be used to reduce the contraction of intestinal smooth muscle.
    AJG049
  • HY-101390A
    (-)-Niguldipine hydrochloride
    		Antagonist
    (-)-Niguldipine ((R)-Niguldipine) hydrochloride is a calcium channel antagonist. (-)-Niguldipine hydrochloride exerts a vasodilatory effect by blocking calcium channels and reducing the transmembrane influx of calcium ions. (-)-Niguldipine can inhibit U-46619 (HY-108566)-induced coronary artery contraction in guinea pig Langendorff hearts (pID50 of 9.93), has high affinity for calcium channel binding sites on guinea pig skeletal muscle membranes (Ki of 8.10), and lowers blood pressure in spontaneously hypertensive rats (pED30 of 5.55). (-)-Niguldipine hydrochloride can improve cardiovascular diseases such as hypertension, angina pectoris, and arrhythmias.
    (-)-Niguldipine hydrochloride
  • HY-106761
    Oxodipine
    		Antagonist
    Oxodipine, a dihydropyridine-type calcium antagonist, inhibits KCl-induced aortic contraction in rabbits and reduces cardiac force in less potent rat ventricular test-paper contractions. In rat cultured neonatal ventricular myocytes, Oxodipine reduces L-type Ca currents (I) with an IC50 of 0.24 μM, and against T-type Ca currents (I) with an IC50 of 0.41 μM. Oxodipine causes constipation in mice and gingival hyperplasia in dogs.
    Oxodipine
  • HY-17436S4
    Clevidipine-15N,d10
    		Antagonist
    Clevidipine-15N,d10 is 15N and deuterated labeled Clevidipine (HY-17436). Clevidipine is a short-acting dihydropyridine calcium channel antagonist (IC50= 7.1 nM, V(H)=-40 mV ).
    Clevidipine-<sup>15</sup>N,d<sub>10</sub>
  • HY-105271
    S-312-d
    		Antagonist
    S-312-d (S-(+)-S-312-d) is a calcium channel blocker with the activity of protecting the kidney from ischemic acute renal failure. S-312-d (0.01-0.1mg/kg b.wt. iv) administered before ischemia has a dose-dependent protective effect on ischemia-induced renal damage, improves the survival rate of ischemic rats, and reduces renal cortical edema and the increase in renal tissue calcium content.
    S-312-d
  • HY-19043
    RS-93522
    		Antagonist
    RS-93522 (RS-93522-004) is a compound with calcium channel antagonist activity that is rapidly absorbed and has high bioavailability via nasal administration.
    RS-93522
Cat. No. Product Name / Synonyms Application Reactivity
Calcium Channel Isoform Comparison

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